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The post hoc analysis of patients only from the PIONEER 6 (evaluating oral semaglutide) and SUSTAIN 6 (evaluating sc semaglutide) studies found a 23.8% reduction in MACEs associated with semaglutide treatment (HR 0.76, 95% CI 0.620.92), especially in the prevention of nonfatal stroke (HR 0.65, 95% CI 0.430.97) [62]

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Supplementation of NR activates SIRT6 expression and delays motor neuron degeneration, reduces neuroinflammation in the spinal cord, and slightly prolongs survival of SOD1 G93A mice (Harlan et al., 2016)

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